The QTc modeling we performed for glasdegib was published in the Expert Review of Clinical Pharmacology.

Link to this article: https://doi.org/10.1080/17512433.2021.1925538

Citation: Luke K. Fostvedt, Naveed Shaik, Giovanni Martinelli, Andrew J. Wagner
& Ana Ruiz-Garcia (2021) Exposure–response modeling of the effect of glasdegib on cardiac
repolarization in patients with cancer, Expert Review of Clinical Pharmacology, 14:7, 927-935, DOI:
10.1080/17512433.2021.1925538

ABSTRACT
Purpose: To characterize the effect of glasdegib on cardiac repolarization (QTc) in patients with
advanced cancer.
Methods: A concentration–QTc model was developed using data from two glasdegib single-agent,
dose-escalation trials. Triplicate electrocardiogram was performed at pre-specified timepoints paired
with pharmacokinetic blood collections after a single dose and at steady-state. Changes in QTc from
baseline were predicted by model-based simulations at the clinical dose (100 mg QD) and in
a supratherapeutic setting.
Results: Glasdegib did not affect the heart rate, but had a positive effect on the corrected QT …

The lorlatinib ADME studies were published in the Journal of Clinical Pharmacology.

Link to the manuscript: https://doi.org/10.1002/jcph.1621

Citation: Stypinski, D., Fostvedt, L., Lam, J.L., Vaz, A., Johnson, T.R., Boerma, J.S. and Pithavala, Y.K. (2020), Metabolism, Excretion, and Pharmacokinetics of Lorlatinib (PF-06463922) and Evaluation of the Impact of Radiolabel Position and Other Factors on Comparability of Data Across 2 ADME Studies. The Journal of Clinical Pharmacology, 60: 1254-1267. 

Abstract: While an initial clinical absorption, distribution, metabolism, and excretion (ADME) study (Study 1; N = 6) with 100 mg/100 µCi [¹⁴C]lorlatinib, radiolabeled on the carbonyl carbon, confirmed that the primary metabolic pathways for lorlatinib are oxidation (N-demethylation, N-oxidation) and N-glucuronidation, it also revealed an unanticipated, intramolecular cleavage metabolic pathway of lorlatinib, yielding a major circulating benzoic acid metabolite (M8), and an unlabeled pyrido-pyrazole substructure. Concerns regarding the fate of unknown metabolites associated with this intramolecular cleavage …

Luke Fostvedt, Dan Nordman, Alyson Wilson

Abstract: We consider a model for generating a random graph using the configuration model. In the configuration model, each node draws a degree independently from a marginal degreed distribution and endpoints pair randomly. We establish non-trivial bounds on the expected sizes of “buckets ” for large graphs. We define nodes i and j in a graph as neighbors if they share an edge, and we define the “bucket ” associated with node i as the set of nodes that are its neighbors and have degree greater than node i. We formalize this argument by providing an analysis for the expected number of items and pairs in a “bucket ” for arbitrarily specified degree distributions, which include power laws.

Paper: Technical Report…

Jonathan Hobbs, Luke Fostvedt, Adam Pintar, David Rockoff, Eunice Kim, and Randy Griffiths

Electoral integrity has been a forefront issue during the past decade. Policy developments such as voter-verified paper records and post-election audits bolster transparency and voter confidence.

paper: pdf…

Study Guide compiled by Cory Lanker and Luke Fostvedt, Iowa State University
Content includes: Sigma Algebras, Measurable Sets, Lebesgue Measures, Lebesgue Integration, General Lebesgue Integrals, Product Measures, Radon-Nikodym Theorem, Fubini and Tonelli’s theorems, Lebesgue Fundamental Theorem of Calculus, Inequalities, Independence, Borel-Cantelli Lemmas, Law of Large Numbers, Convergence in Probability, Convergence is Distribution, Kolmogorov Theorems, Continuous Mapping Theorem, Tightness, and Method of Moments.

Source: class notes by Dan Nordman, Fall 2009, STAT642, and “Real Analysis” by H. Royden and “Measure Theory” by P.R. Halmos. All references in this document are to Professor Dan Nordman’s class notes.
Content: This study guide is a good supplement to the Athreya Lahiri Text.

Study Guide: Measure Theory and Probability Theory Study Guide
…